Inhibitor Screening Services

High-Quality, Customised Screening for Novel Compound Inhibitors

Accelerate your research with dependable inhibitor screening tailored to your specific targets and assay formats

Precise & Reproducible

Validated assays and meticulous QC ensure consistent, publishable data.

Flexible Formats

From single enzyme screens to high-throughput multi-compound studies customised to your workflow.

Scientifically Supported

Work directly with experienced enzymologists to refine your assay design and interpret results.

Service Overview

Custom Inhibitor Screening

Whether you’re validating lead compounds, characterising enzyme mechanisms, or comparing inhibitor selectivity, our screening services provide the insight and reliability required for confident decision-making.

Inspiralis offers a broad range of biochemical and biophysical screening options, including:

  • IC₅₀ and Ki determination
  • Competitive, non-competitive, and mixed-mode inhibition analysis
  • Screening against DNA-modifying enzymes, topoisomerases, and other key molecular targets
  • Custom assay development for non-standard substrates or conditions

Each project is tailored to your research goals, with transparent data reporting and full documentation. From early discovery to pre-clinical support, our team ensures accuracy, reproducibility, and clear communication at every stage.

Trusted Expertise

About Inspiralis

Based at the Norwich Research Park, Inspiralis is a leading provider of DNA-modifying enzymes, custom protein expression, and inhibitor screening solutions.

With over 15 years’ experience supporting the biotech and pharma sectors, we combine scientific rigour with responsive project management, helping research teams meet demanding timelines without compromising data quality.

Our laboratories operate to ISO and GMP principles, with every assay activity-tested and reproducibility verified.

Why Choose Inspiralis?

The Benefits of Choosing Inspiralis

  • Custom assays designed for your targets

  • Exceptionally agile, enabling rapid turnaround and responsive support.

  • 15+ years of experience as experts in DNA and DNA-modifying enzymes.

  • Quality-driven across every stage, from expression to final QC.

  • Consistently reliable production with reproducible results across all batches.

  • AI-powered enzyme engineering coming soon for smarter design solutions.

Alternative Supplier

  • Often limited to standard catalogue offerings with minimal customisation.

  • Slower response times and less adaptable to changing project needs.

  • Broader focus, with less depth in specialised enzyme systems.

  • Quality may vary with fewer controls in place for custom projects.

  • Reproducibility can be a challenge across batches or suppliers.

  • Limited innovation; slower to adopt emerging technologies like AI.

We selected Inspiralis as our supplier because their product was far and away the highest quality, and excellent value. However, beyond their product quality and consistency, we found Inspiralis to be an incredibly communicative and collaborative partner – going above and beyond providing us data to enable our own process development, sourcing a boutique shipping company to ensure our high-dollar-value shipment arrived safely and still frozen, or working at all hours to produce an extra large, last-minute, and highly urgent request. I would very happily work with Inspiralis again in the future.
Manager of Operations & Planning, A Gene Therapy Coompany, USA
The KDNA we purchased from Inspiralis is much better than the one from Inspiralis’s competitors. We have noticed a significant improvement in stability and reproducibility of results when we started to use KDNA from Inspiralis. We have also performed super resolution microscopy and AFM on the KDNA and the integrity and purity of the samples are by far the best.
Davide Michieletto, Royal Society University Research Fellow
What truly sets Inspiralis apart is their deep understanding of the research process and the needs of researchers. They are not merely suppliers but true research partners. Their team is consistently communicative, collaborative, and proactive, often going above and beyond to ensure our projects run smoothly.
I am thoroughly satisfied with their partnership and I will not hesitate to work with Inspiralis again in the future. Their speed, quality, and dedication to understanding our research needs have made all the difference. We have published more than 20 papers on bacterial gyrase and human Topoisomerase, and Inspiralis’ expertise was an important factor in our success, highlighting their commitment to advancing scientific knowledge.
Prof. Dr. Janez Ilaš, Professor of Medicinal Chemistry - University of Ljubljana, Faculty of Pharmacy

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